Mercer Gallery is located in the west wing of the Pauline Joyce Fine Arts Building at Garden City Community College. The campus is on the east side of Garden City, just west of Campus Drive and just south of Kansas Avenue.

The Pauline Joyce Fine Arts Building, which includes a theater, art studios, piano lab, classrooms and music rooms in addition to the gallery, is located near the north side of the campus, just across the street southwest from the Physical Education Building and immediately west of the Warren L. Fouse Science and Math Building.

The gallery may be reached from the south main entrance of the Joyce Building, or more directly from the door which opens onto the north fine arts parking lot. The north door is marked by a distinctive Mercer Gallery canopy.